Researchers identified 92 circulating proteins that cross the blood-brain barrier and enter brain tissue, revealing how proteins such as liver-derived APOA1 help regulate astrocyte cholesterol metabolism and support neuronal synapses. In an Alzheimer’s disease mouse model, APOA1 transport was impaired, but increasing its production in the liver reduced selected inflammatory and amyloid-related abnormalities, improved synaptic integrity, and enhanced some measures of memory.
